EP 237: Setting Smart Goals: A Nurse’s Guide to New Year Success

EP 237: Setting Smart Goals: A Nurse’s Guide to New Year Success

Navigating Career Goals in Nursing: From New Grad to Advanced Practice

The journey of a nurse is as diverse and dynamic as the field of healthcare itself. From the moment a new graduate nurse steps onto the unit, to the seasoned professional aiming for advanced roles, each step brings its own set of challenges and rewards. In our latest podcast episode, we delve into the world of nursing careers, offering insights and encouragement for nurses at every stage of their journey.

The First Steps: Embracing Your Role as a New Grad Nurse

Starting out in nursing can be overwhelming. New graduates often find themselves trying to absorb a vast amount of information, adapt to the pace of healthcare settings, and find their footing among seasoned professionals. It’s important for new nurses to recognize that getting comfortable on the unit is a significant achievement in itself. Seeking mentorship, embracing the learning curve, and gradually building confidence are key steps in this initial phase.

Aspiring Towards Leadership

For those looking to move beyond bedside nursing, roles such as charge nurse, nurse educator, and nurse manager present exciting opportunities. Achieving these positions requires not just clinical expertise, but also strong leadership, communication, and organizational skills. We discuss the pathways to these roles and how nurses can prepare themselves for leadership positions, emphasizing the importance of continuous learning and professional development.

The Pursuit of Advanced Education

The field of nursing offers vast opportunities for those willing to advance their education. Whether it’s becoming a Nurse Practitioner (NP) or a Certified Registered Nurse Anesthetist (CRNA), advanced degrees open new doors for career growth and specialization. Our episode explores the challenges and rewards of pursuing higher education while balancing work and personal life, providing listeners with practical advice on navigating this ambitious path.

Maintaining Mental and Physical Health

Nurses are no strangers to the pressures and demands of healthcare. The emotional toll of dealing with life-and-death situations, combined with the physical demands of long shifts, can impact even the most resilient professionals. We delve into the importance of mental and physical health, offering strategies for managing stress, building resilience, and maintaining well-being amidst the challenges of nursing.

Resilience: The Heart of Nursing

Perhaps the most vital trait for nurses is resilience. The ability to face adversity, adapt to change, and emerge stronger is crucial in a profession that deals with human suffering and constant challenges. Our episode shares inspiring stories of nurses who have demonstrated incredible resilience, providing listeners with insights into how they can cultivate this quality in their own lives.

The nursing profession is a journey of continuous growth, learning, and adaptation. By setting thoughtful goals, pursuing further education, and prioritizing our health and resilience, nurses can navigate their careers with confidence and purpose. As we support one another in reaching our fullest potential, we not only advance our own careers but also contribute to the betterment of healthcare as a whole.

Full Episode: https://youtu.be/7EqxUF3Zpdk 

  1. Instagram: https://www.instagram.com/cupofnurses/
  2. Website: https://fanlink.to/CONsite
  3. Shop: https://fanlink.to/CONshop
  4. Free Travel Nursing Guide: https://fanlink.to/Travelnursingchecklist
  5. Nclex Guide: https://fanlink.to/NCLEXguide
  6. Interested in Travel Nursing? https://fanlink.to/TravelNurseNow
  7. YT: https://www.youtube.com/@CUPOFNURSES
EP 212: A Patient’s Perspective of Delirium With Amelie Susanne

EP 212: A Patient’s Perspective of Delirium With Amelie Susanne

EP 212: A Patient’s Perspective of Delirium With Amelie Susanne

What is a patient’s perspective of delirium? An induced coma is also known as MIC or medically induced coma, barbiturate-induced coma, or drug-induced coma.

It is also called as temporary coma or a deep state of consciousness controlled by an anesthetic drug.

Often, barbiturates like pentobarbital or thiopental are used to help patients. It can also be intravenous anesthetic drugs like midazolam or propofol, but what happens when a patient goes through an induced coma and wakes up from it?

Can a patient recall any memory while they are in a coma? This episode will talk about a patient’s perspective of delirium and many more. 

In this episode, we would like to introduce you to Amelie Susanne Roth. Susanne is a coma survivor. After an initial bacteria infection, Susanne had to be placed into an induced coma that lasted 16 days.

We talk about her time in the ICU and her experience of being in a coma and suffering from it. In this episode, we flip the script and learn firsthand about the patient’s experience.  

 

Questions for Our Guest

The questions below are some we’d like to tackle. We often go off-topic, so we don’t expect to hit them all. If you have any ideas, please let us know.

Looking forward to our conversation!

These are the questions you had in Calendly. We’ll go off our questions, and wherever else our conversation goes.

  1. Please give us a little background about yourself.
  2. How did you end up in the hospital? And can you go a little in-depth into what happened?
      • Do you know what kind of infection it was? Where it came from?

3. Can you put us through the course of your hospital experience? Before this, coming from the day you came in?

      • What you heard, what were you told, and how did you feel?

4. You going into a coma and being intubated; was this something you expected? 

5. When you were intubated and unresponsive, what was happening? 

      • Do you remember any of it? 
      • How did it feel?
      • Were you able to hear anything?
      • Was it just like a dream state?

6. When you came out of the coma, were you mentally back to normal?

      • Were you aware of the whole extubation process? For example, when nurses say, can you open your eyes, squeeze my hand, weaning process?
      • Did you suffer from any delirium or confusion?
      • How did you feel during everything that was going on?

7. Where do you think healthcare providers can improve?

8. What was the process after you regained consciousness?

      • Did it take you a long time to bounce back? PT/OT? What does PT/OT mean?

9. How has life changed for you?

      • Additionally, did you have any big realizations? Like a change in mentality or outlook? 

10. What made you decide to write a book?

 

Ending Questions

Before we end the show, we have one last question we like to ask all our guests.

If you had the opportunity to have a Cup of coffee with anybody one last time, who would it be and why? 

 

Links: 

www.ameliesusanneroth.com
https://a.co/d/efqtaHD

Do you want to learn more about a patient’s perspective of delirium? Watch the full episode here 👇👇

TIMESTAMPS:

00:00 Introduction
01:32 About Amelie Susane Roth
02:38 How it all started
07:25 Experiences of Being Under Sedation and in a Coma
13:40 How does it feel to be in delirium or a coma?
15:57 A better understanding of why a patient gets agitated
18:14 The post-coma experience
25:03 Medicine Failing Patients and the Need for a Different Approach
27:50 Coping with Traumatic Experiences After a Coma
35:00 Life’s outlook after coma
40:48 Amelie’s life prior to becoming a patient
44:27 The Life Lessons While Traveling The World
47:18 Wrapping up the show

EP 205: 9 Qualities of a Good Nurse

EP 205: 9 Qualities of a Good Nurse

9 Qualities of a Good Nurse

In this episode, we will discuss the nine qualities of a good overall nurse. It is undeniable that nursing is a noble profession that requires a unique set of skills and qualities.

It is not an easy job, and nurses must possess several qualities that make them stand out. In this podcast, we will discuss nine qualities that every aspiring nurse should strive to have.

1. Be a team player – hard work ethic.

One of the most important qualities of a good nurse is being a team player with a strong work ethic.  Nurses should be willing to work collaboratively with their colleagues and be proactive in helping them.

Even if your shift is difficult, can you still go out of your way to help another nurse? What if you’re busy and your co-worker wants a 15 min break? Will you say no? Do it for the squad! In some units, you know the team got you back.

2. Learn to communicate with everybody on the healthcare team

Communication is another critical skill that every good nurse should have. Nurses interact with several people, including patients, families, physicians, and other healthcare professionals.

Therefore, excellent communication skills are a must. Nurses should be able to convey information, listen actively, and respond appropriately. Effective communication ensures that patients receive quality care and that the healthcare team works together seamlessly.

3. Flexibility in your shift – going with the flow

Flexibility is also crucial in nursing. Nurses must work flexible hours, including night shifts, weekends, and holidays or even deal with floating multiple times a shift as we did in our travel nursing contract.

Flexibility helps ensure that patients receive the care they need and that the healthcare team is adequately staffed. Can you float as a nurse without negatively impacting your team?

4. Don’t be hyper-independent and not help others

While nurses need to be independent and resilient, they should also be careful not to be hyper-independent and not help others. Nurses work in teams, and every team member should be willing to help their colleagues.

Being a team player means being willing to lend a helping hand, ask for help when needed, and work collaboratively to achieve the best patient outcomes. This is what makes you a high-quality nurse to be around. 

5. Having empathy – compassionate 

Empathy is another crucial quality of a good nurse. Nurses should be empathetic and compassionate towards their patients.

They should be able to connect with their patients, show them kindness, and provide emotional support. Having empathy helps patients feel valued, understood, and cared for, which can positively impact their recovery.

6. Emotional Stability – Tempered 

Nursing is a challenging job that can be emotionally draining. Thus, a good nurse should be emotionally stable and tempered.

They should be able to manage their emotions, remain calm under pressure, and handle stressful situations effectively.

Emotional stability helps nurses provide quality care and maintain a positive work environment.

7. Attention to detail 

Attention to detail is another critical quality for nurses. Nurses are responsible for administering medications, monitoring vital signs, and providing treatments. Therefore, they should be meticulous and detail-oriented.

Paying attention to detail ensures that patients receive the right medication, dosage, and treatment, which can significantly impact their recovery or potentially cause harm.

8. Problem-solving skills – a Critical thinker 

Problem-solving skills are also essential for nurses. Nurses encounter complex problems daily and must be able to solve them effectively. A good nurse should be a critical thinker and possess problem-solving skills.

They should be able to assess a situation, identify the problem, and develop a plan to solve it. If you don’t know how to solve the problem, who can you escalate the situation to (chain of command)? 

Problem-solving skills help nurses provide quality care and improve patient outcomes.

9. Patient advocate 

The core of nursing is centered around being a patient advocate. They should speak up for their patients, protect their rights, and provide the best possible care.

Being a patient advocate requires nurses to be knowledgeable, assertive, and proactive in advocating for their patient’s needs.

In Closing

In conclusion, becoming a successful and effective nurse involves possessing several qualities. These qualities include being a team player, having excellent communication skills, being flexible, empathetic, emotionally stable, detail-oriented, possessing problem-solving skills, and being a patient advocate.

Every aspiring nurse should strive to possess these qualities to provide quality patient care, maintain a positive work environment, and achieve the best outcomes for patients.

Do you have all the qualities of a good nurse? Check out the full episode here 👇👇👇

TIMESTAMPS:

00:00 Introduction
02:09 1. Be a team player – hard work ethic
04:00 2. Learn to communicate with everybody on the healthcare team
06:03 3. Flexibility in your shift -going with the flow
09:50 4. Don’t be hyper-independent and not help others
13:32 5. Having Empathy – Compassionate
17:53 6. Emotional Stability – Tempered
23:47 7. Attention to detail
27:02 8.Problem-solving skills – Critical thinker
29:53 9. Patient Advocate
35:02 Wrapping up the show

 

EP 201: Lab Values to Know as a Nurse

EP 201: Lab Values to Know as a Nurse

Lab Values to Know as a Nurse

What are the lab values to know as a nurse? Lab values and what they show could mean so many things. They are used to determine the patient’s overall well-being and health and on nurses to base their care plan.

Different factors affect the patient’s lab values result, but the most common factors affecting it are the patient’s age, race, gender, medical history, and presence of any underlying conditions. Knowing and understanding lab values is essential in your nursing career.

There are different lab values to know as a nurse. In this episode, we will talk about all the different labs we look at in the hospital. We will go over their normal values, what they signify, and what can happen if they are out of their normal range.

This will be a good refresher episode for everyone who deals with labs and a great one for any nursing students because these are the labs you’ll need to know to pass some of your classes and the NCLEX.

Electrolytes

Potassium K+

  • Potassium is one of the most important minerals in the body. It helps regulate fluid balance, muscle contractions, and nerve signals. 
  • Normal level: 3.5-5 mEq/L
    • Hyperkalemia signs: heart arrhythmias, numbness, and tingling, breathing problems
    • Hypokalemia signs: muscle weakness, fatigue, heart arrhythmias
  • Clinical problem
    • Increased level: Acute renal failure, Crushed/burn injury, acidosis 
    • Decreased level: vomiting/diarrhea, dehydration, malnutrition, gastric suction, Diuretics 

Sodium Na+ 

  • Sodium plays a key role in your body. It helps maintain normal blood pressure, supports the work of your nerves and muscles, and regulates your body’s fluid balance.
  • Normal level: 135-145 mEq/L
    • Hypernatremia signs: lethargy, myoclonic jerks, confusion, nystagmus, tachycardia
    • Hyponatremia  signs: nausea and vomiting, lethargy, seizure, neurological deficits
  • Clinical problem
    • Increased level: Dehydration, severe vomiting, diarrhea, Heart failure, hepatic failure, Cushing’s disease 
    • Decreased level: vomiting, diarrhea, gastric solution, D5W, SIADH,

Calcium Ca+ 

  • It is a mineral that is necessary for life. In addition to building bones and keeping them healthy, calcium enables our blood to clot, our muscles to contract, and our heart to beat. About 99% of the calcium in our bodies is in our bones and teeth.
  • Normal level: 8.5 to 10.2 mg/dL
    • Hypercalcemia signs: bone pain, muscle weakness, excessive thirst, lethargy, nausea
    • Hypocalcemia signs: numbness and tingling in digits, muscle cramps, wheezing, fatigue
  • Clinical problem
    • Increased level: Hyperparathyroidism, malignant neoplasm of bone, lung, breast, kidney, multiple myeloma, and prolonged immobilization. 
    • Decreased level: Diarrhea, malabsorption of calcium, Hypoparathyroidism

Chloride CI- 

  • Chloride is one of the essential electrolytes in the blood. It helps keep the amount of fluid inside and outside of your cells in balance. It also helps maintain proper blood volume, blood pressure, and pH of your body fluids.
  • Normal level: 95-105 mEq/L
    • Hyperchloremia signs: diarrhea, vomiting, fatigue, dry mucous membrane
    • Hypochloremia signs: diarrhea, vomiting, weakness, dehydration
  • Clinical problem
    • Increased level: Dehydration, hypernatremia, head injury, metabolic acidosis.  
    • Decreased level: Vomiting, gastric suction, diarrhea, hypokalemia. 

Magnesium Mg+

  • It helps to maintain normal nerve and muscle function, supports a healthy immune system, keeps the heartbeat steady, and helps bones remain strong. It also helps adjust blood glucose levels. It aids in the production of energy and protein.
  • Normal level: 1.5-2 mEq/L
    • Hypermagnesemia: diminished deep tendon reflexes, flushing, headache, nausea, drowsiness.
    • Hypomagnesemia: muscle weakness, twitches, or tremors; irritability, insomnia, drowsiness
  • Clinical problem
    • Increased level: Severe dehydration, renal failure, leukemia
    • Decreased level: Protein malnutrition, malabsorption, cirrhosis of the liver, alcoholism, hypokalemia

Phosphorus 

  • It is a mineral that makes up 1% of a person’s total body weight. It is the second most abundant mineral in the body. It is present in every cell of the body. Most of the phosphorus in the body is found in the bones and teeth.
  • Normal level: 2.5-4.5 mg/dl
    • Hyperphosphatemia signs: osteoporosis, cardiovascular disease
    • Hypophosphatemia signs: changes in mental state, bone pain/fragility, fatigue, weight loss, weakness
  • Clinical problem
    • Increased level: Renal failure, hypocalcemia, hypoparathyroidism 
    • Decreased level: starvation, hypercalcemia, hypomagnesemia, chronic alcoholism

Ammonia

  • Ammonia is a waste product made by your body during protein digestion.
  • Normal level: 15-50 μmol/L
    • Hyperammonemia signs: Lethargy (ETOH Pt), rapid or heavy breathing, Altered mental status 
  • Clinical problems
    • Increased level: Hepatic failure, High protein diet with liver failure, acidosis. 

Uric acid 

  • It is a chemical created when the body breaks down substances called purines.
  • Purines are usually produced in the body and are also found in some foods and drinks.
  • Normal level 0.18-0.48 mmol/L
    • High signs: Joint pain, joint stiffness, redness, and swelling. 
  • Clinical problems
    • Increased level: Gout, alcoholism, severe eclampsia, renal failure

Creatinine

  • Creatinine is a waste product produced by muscles from the breakdown of a compound called creatine. It is removed from the body by the kidneys.
  • Normal level 0.8-1.3 mg/dL
    • High signs: Nausea, muscle cramps, vomiting, fatigue, HTN
  • Clinical problem
    • Increased level: Hypothyroidism, CKD, intense exercise, dehydration 
    • Decreased level: Renal impairment, hyperthyroidism, ALS

BUN 

  • BUN is the end product of protein metabolism and is excreted by the kidneys
  • Normal level 8-21 mg/dL
    • High signs: Frequent urination, itching, muscle cramps, fatigue. 
  • Clinical problem
    • Increased level: Dehydration, GI bleeding, prerenal failure, Acute MI, sepsis, shock
    • Decreased level:  Severe liver damage, overhydration, malnutrition

Specific Gravity

  • A urine-specific gravity test compares the density of urine to the density of water. This quick test can help determine how well your kidneys dilute your urine.
  • Normal level 1.010-1.030 
    • High signs: Dehydration, Diabetes, Proteinuria, SIADH
    • Low signs: Polydipsia, Diabetes Insipidus, Diuretics, early stages of CKD

LDH 

  • Lactic dehydrogenase (LDH) is an intracellular enzyme in nearly all metabolizing cells, with the highest concentration in the heart, skeletal muscle, liver, kidney, brain, and RBCs.
  • Normal level 50-150 U/L
    • Increased level: Acute MI, P.E, Sepsis, shock, CVA, sickle cell.

Hematology

RBC 

  • The reticulocyte count is an indicator of bone marrow activity
  • Normal level 4.5-5.0 million
    • Increased level: sickle cell, hemolytic anemia, leukemias 
    • Decreased level: Anemia, radiation therapy, post hemorrhage, cirrhosis of the liver (alcohol suppresses reticulocytes)

WBC 

  • White blood count, part of a complete blood count, is composed of 5 types of WBCs 
  • Normal level 5,000-10,000
    • Increased level: Acute infection, Inflammatory diseases (RA, gout), Tissue damage (acute MI, burns)
    • Decreased level: leukemias, immunosuppressive agents

Plt 

    • Platelets (thrombocytes) are essential elements in the blood that promote coagulation.
  • Normal level 200,000-400,000
    • Increased level: Polycythemia vera, trauma, acute blood loss, Metastatic carcinoma
    • Decreased level: Multiple myeloma, Anemias, Leukemias, liver disease, lupus, DIC, Cirrhosis 

Hgb 

  • Hemoglobin responsible for the transportation of oxygen
  • Normal level 
    • male 13-17 g/dL
    • female 12-15 g/dL
  • Increased level: Dehydration, polycythemia, COPD, HF, severe burns
  • Decreased level: Anemias, Hemorrhage, cirrhosis of the liver, Leukemias, Hodgkin’s disease, kidney disease

Hematocrit 

  • The hematocrit is a ratio of the volume of red blood cells to the volume of all these components, called whole blood. The value is expressed as a percentage or fraction.
  • Normal level Male 40%-52% Female 36%-47%
    • Increased level: Dehydration/hypovolemia, severe diarrhea, diabetic acidosis, burns.
    • Decreased level: Acute blood loss, anemias, RA, lupus, CKD, cirrhosis

PTT 

  • Partial thromboplastin time (PTT) is a blood test that looks at how long it takes for blood to clot. It can help tell if you have a bleeding problem or if your blood doesn’t clot properly.
  • Normal level 25-35 sec.  If on Heparin 1.5-2.5x normal
    • Increased level: Hemophilia, cirrhosis, vitamin k deficiency, Von Willebrand disease, DIC. 

PT 

  • Prothrombin Time. It is synthesized by the liver and is an inactive precursor in the clotting process.  
  • Normal level 11- 14 sec
    • Increased level: Liver disease, Clotting factor issues (Factor 2 deficiency), Heart failure, leukemias
    • Decreased level: Thrombophlebitis, MI, P.E 

INR 

  • The international normalized ratio (INR) is a laboratory measurement of how long it takes blood to form a clot. It is made to monitor patients receiving warfarin. 
  • Normal level 0.9-1.2 If on Coumadin 1.5 – 3

Reticulocytes

  • Reticulocytes are immature red blood cells (RBCs).
  • Normal range  0.5-1.5%

Neutrophils 

  • Are the most numerous circulating WBCs, respond mainly to inflammation & tissue injury.
  • Normal range 2-8 x 10^9/L

Bands 

  • Basophils increase during the healing process
  • Basophils are white blood cells that defend your body from allergens. Basophils release histamine
  • Normal Range < 1 x 10^9/L

Lymphocytes 

  • Increased during chronic and viral infections
  • Normal range 1-4 x 10^9/L

Monocytes 

  • The second line of defense. More extensive and more substantial than neutrophils can ingest large particles and debris.
  • Normal range 0.2-0.8 x 10^9/L

Eosinophils 

  • Increase during allergic and parasitic conditions 
  • Normal level < 0.5 x 10^9/L

HBA1C 

  • The hemoglobin A1c test tells you your average blood sugar level over the past 2 to 3 months. It’s also called HbA1c, glycated hemoglobin test, and glycohemoglobin.
  • Normal level <6.5%

Glucose 

  • Simple sugar is used as an energy source and is stored as glycogen in the liver and skeletal muscles.
  • Normal level 70-110 mg/dL
    • Increased level: DM, Diabetic acidosis, adrenal gland hyperfunction (Cushing’s) 
    • Decreased level: Hypoglycemia, malnutrition

Gastrointestinal

Bilirubin

  • Bilirubin is formed from the breakdown of hemoglobin by the reticuloendothelial system and is carried in the plasma to the liver. Bilirubin (unconjugated or indirect) is bound to serum albumin and transferred to the liver, which is conjugated to glucuronate by glucoronyl transferase. Conjugated (direct) bilirubin is excreted into the bile.
  • Normal level 
    • Direct Bilirubin 0-6 µmol/L 
    • Total Bilirubin 2-20 µmol/L
  • Increased level: Obstructive jaundice caused by stones, hepatitis, cirrhosis, liver cancer
  • Decreased level: Iron-deficiency anemia. 

Albumin 

  • Albumin is a protein made by your liver. Albumin helps keep fluid in your bloodstream so it doesn’t leak into other tissues. It also carries various substances throughout your body, including hormones, vitamins, and enzymes.
  • Normal level 35-50 g/L
    • Increased level: Dehydration, severe vomiting, severe diarrhea 
    • Decreased level: Cirrhosis of the liver, acute liver failure, severe burns, severe malnutrition, preeclampsia, renal disorders, prolonged immobilization. 

ALT/AST

  • ALT/AST is an enzyme found primarily in the liver cells and is effective in diagnosing hepatocellular destruction.
  • Normal level 5-30 U/L
  • Increased level: Acute (viral) hepatitis and liver necrosis (Drug or chemical toxicity).

Amylase 

  • Amylase is an enzyme derived from the pancreas, the salivary glands, and the liver. Its function is to change starch to sugar. 
  • Normal level: 30-125 U/L
  • Increased level: Acute pancreatitis, obstruction of the pancreatic duct, acute cholecystitis, diabetic acidosis, diabetes mellitus, renal failure. 

Lipase 

  • Lipase, an enzyme secreted by the pancreas, aids in digesting fats. Appears in the bloodstream following damage to the pancreas. 
  • Normal level: 10-150 U/L
  • Increased level: Acute and chronic pancreatitis, cancer of the pancreas, and obstructions. 

Hormones

Hydroxyprogesterone 

  • IHydroxyprogesterone is a hormone made by the adrenal glands, two glands on top of the kidneys. A 17-OHP test is used for Hydroxyprogesterone levels to help diagnose a rare genetic disorder called congenital adrenal hyperplasia.
  • Normal level: 0.2-1 mg/L

Adrenocorticotropic ACTH 

  • Adrenocorticotropic hormone (ACTH) is made in the pituitary gland. It is needed for your adrenal glands to work properly and help your body react to stress. ACTH stimulates the release of another hormone called cortisol from the adrenal gland’s cortex (outer part).
  • Normal level: 4.5-20 pmol/
  • Increased level: Addison’s disease, Stress, pituitary neoplasm, pregnancy. 
  • Congenital adrenal hyperplasia (CAH) refers to a group of genetic disorders that affect the adrenal glands, a pair of walnut-sized organs above the kidneys. The adrenal glands produce essential hormones, including Cortisol, which regulates the body’s response to illness or stress.

TSH 

  • Thyroid-stimulating hormone is a pituitary hormone that stimulates the thyroid gland to produce thyroxine (T3), and triiodothyronine (T4)  which stimulates the metabolism of almost every tissue in the body.
  • Normal level: 0.5-5 mIU/L
  • Increased level: Hypothyroidism, acute thyroiditis, viral hepatitis, myasthenia gravis, preeclampsia
  • Decreased level: Hyperthyroidism

Thyroxine

  • Serum T4 levels are commonly used to measure thyroid hormone concentration and the function of the thyroid gland. 
  • So, if your T3 and T4 levels are too low, the pituitary gland will release more TSH. If they’re too high, the gland will release less TSH — but this give-and-take system only works if everything functions properly.
  • Normal level:
    • Free T3 0.2-0.5 ng/dL
    • Free T4 10-20 pmol/L
    • Total T4 4.9-11.7 mg/dL
    • Total T3 0.7-1.5 ng/dL
  • Increased level: Hyperthyroidism, acute thyroiditis, myasthenia gravis, preeclampsia
  • Decreased level: Hypothyroidism, Protein malnutrition.

Follicle-stimulating hormone 

  • FSH, a gonadotropic hormone produced and controlled by the pituitary gland, stimulates the growth and maturation of the ovarian follicle to produce estrogen in females and promote spermatogenesis in males. 
  • Normal level:
    • (FSH) 1-10 IU/L (M/F) 
    • 5-25 IU/L (ovulation) 
    • 30-110 IU/L (postmenopause)
  • Increased level: Gonadal failure such as menopause, Pituitary tumor, Turner’s syndrome, Klinefelter’s syndrome 
  • Decreased level: Neoplasms of the ovaries, testes, adrenal: polycystic ovarian disease, hypopituitarism; anorexia nervosa. 

Growth Hormone 

  • Human growth hormone (hGH), a hormone from the anterior pituitary gland, regulates the growth of bone and tissue. 
  • Normal level: (fasting) 0-5 ng/m
  • Increased level: Gigantism (children), Acromegaly (adults), major surgery. 
  • Decreased level: dwarfism in children, hypopituitarism

Progesterone 

  • It is secreted by the corpus luteum, a temporary endocrine gland that the female body produces after ovulation during the second half of the menstrual cycle.
  • Normal level 70-280 ng/dL
  • Increased level: Ovulation, pregnancy, ovarian cysts, tumors of the ovary or adrenal gland. 
  • Decreased level: Gonadal dysfunction, luteum deficiency, threatened abortion, placental failure.

Prolactin 

  • It is a hormone produced by your pituitary gland, which sits at the bottom of the brain. Prolactin causes breasts to grow and develop and causes milk to be made after a baby is born. 
  • Normal level: < 14 ng/mL
  • Increased level: Pregnancy, breastfeeding, pituitary tumor, amenorrhea, hypothalamic disorder, endometriosis, chronic renal failure, Addison’s disease.
  • Decreased level: Postpartum pituitary infarction

Testosterone (male):  

  • Testosterone is the primary male sex hormone and an anabolic steroid. In male humans, testosterone plays a crucial role in developing male reproductive tissues such as the testes and prostate and promoting secondary sexual characteristics such as increased muscle and bone mass and body hair growth.
  • Normal level: 10-25 nmol/L
  • Increased level: Adrenal hyperplasia or tumor, polycystic ovaries in females
  • Decreased level: Testicular hypofunction, Klinefelter’s syndrome (primary hypogonadism), Alcoholism, hypopituitarism

Lipids

LDL 

  • LDL stands for low-density lipoproteins. It is sometimes called the “bad” cholesterol because a high LDL level leads to a buildup of cholesterol in your arteries.
  • Normal level: 85-125 mg/dL
  • Saturated fat and cholesterol in your food make your blood cholesterol level rise.

HDL 

  • HDL stands for high-density lipoproteins. It is sometimes called the “good” cholesterol because it carries cholesterol from other parts of your body to your liver. Your liver then removes the cholesterol from your body.
  • Normal level: 40-80 mg/dL

Triglycerides 

  • Triglycerides are a type of fat (lipid) found in your blood. When you eat, your body converts any calories it doesn’t need to use right away into triglycerides. The triglycerides are stored in your fat cells.
  • Normal level: 50-150 mg/dL
  • Increased level: Hyperlipoproteinemia, acute MI, Hypertension, cerebral thrombosis, hypothyroidism
  • Decreased level; Hyperthyroidism, hyperparathyroidism, and protein malnutrition.

Total chol 

  • A measure of the total amount of cholesterol in your blood. It includes low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol.
  • Normal level: 3-5.5 mmol/L

Cardiac Markers

Creatine kinase

  • Creatine kinase is an enzyme found in the heart, brain, skeletal muscle, and other tissues. Increased amounts of CK are released into the blood when there is muscle damage. 
  • Normal level:  25-200 U/L
  • Increased level: exercise and inflammation of muscles, called myositis, and myopathies such as muscular dystrophy. Rhabdomyolysis.

Troponin 

  • Troponins are a group of proteins found in skeletal and heart (cardiac) muscle fibers that regulate muscular contraction—used for cardiac disease diagnosis of acute MI.
  • Normal level: 0-0.4 ng/mL
  • Increased level: MI, myocardial damage

C-reactive protein 

  • It is produced in the liver in response to tissue injury and inflammation. 
  • Normal level < 5 mg/L
  • Increased level: Chronic infections, cardiovascular and peripheral disease, acute MI, Stroke, inflammatory bowel disease, RA, Lupus, bacterial meningitis.

D-dimer 

  • D-dimer is a fibrin degradation product, a small protein fragment in the blood after a blood clot is degraded by fibrinolysis.
  • Normal level: < 500 ng/mL
  • Increased level: DIC, P.E, Thrombosis, COVID 

BNP

  • Brain Natriuretic peptide is a neurohormone secretion primarily in the cardiac ventricles and will increase in response to volume expansion and pressure overload.
  • Normal level:  < 100 pg/ml
  • Increased level: Heart failure, Left ventricular hypertrophy, myocarditis, AMI, Renal failure, prolonged systemic hypertension.

Tumor Markers 

Alpha-fetoprotein 

  • Serum alpha-fetoprotein (AFP), a screening test, is usually done between 16 and 20 weeks gestation to determine the probability of twins or to detect low birth weight or severe birth defects, such as neural-tube defects. 
  • Normal level: 0-44 ng/mL
  • Increased level: Cirrhosis of the liver, hepatitis, Spina bifida, Fetal death, fetal distress, Turner’s syndrome
  • Decreased level: Down’s syndrome, absence of pregnancy

HCG 

  • Human chorionic gonadotropin is a hormone produced by cells that surround a growing embryo, which eventually forms the placenta after implantation. The presence of hCG is detected in some pregnancy tests. Appears in the blood and urine 14-26 days after conception.
  • Normal level: <5 IU/I
  • Increased level: Pregnancy, Chorionepithelioma of pregnancy is a malignant tumor originating in connection with pregnancy. 
  • Decreased level: Nonpregnant, dead fetus, postpartum (3-4 days)

CA 19-9

  • Cancer Tumor Markers (CA 19-9) is a cancer antigen in diagnosing pancreatic, hepatobiliary, gastric, and colorectal cancer. 
  • Normal level: <40 U/mL
  • Decreased levels = Effective response to treatment, benign disease
    • There are also different tumor markers. You won’t need to know all of these, but we thought we should include them. 
    • CA 15-3: Metastatic breast cancer, ovarian, lung, pancreas, cirrhosis, colon cancer.
    • CA-27.29: Recurrence of breast cancer
    • CA 50: Gastrointestinal tumor, biliary tract tumors
    • CA 125: Ovarian breast cancer, uterine tumors, pancreas, breast, colon, lung, cirrhosis, pancreatitis.  

CEA 

  • Carcinoembryonic antigen (CEA) has been found in the gi epithelium of embryos and has been extracted from tumors in the adult gastrointestinal tract. 
  • Normal level: <4 ug/L
  • Increased level: GI tract (esophagus, stomach, small and large intestine, rectum cancer), leukemia, Ulcerative colitis. 

PAP 

  • Prostatic acid phosphatase (PAP) originates in the prostate and usually is present in small amounts in the blood. 
  • Normal level: 0-3 U/dL
  • Increased level: prostate cancer, testicular cancer, leukemia, and non-Hodgkin’s lymphoma.

 

PSA 

  • Prostate-specific antigen (PSA) is always present in low concentrations in the blood of adult males.
  • Normal level: <4 ug/L
  • Increased level: Prostate cancer

Vitamins 

Folate 

  • Folate is one of the B vitamins needed to make red and white blood cells in the bone marrow, convert carbohydrates into energy, and produce DNA and RNA.
  • Normal level: 7-36 nmol/L
  • Increased level: Pernicious anemia (is a deficiency in red blood cells caused by lack of vitamin B12)
  • Decreased level: Folic acid anemia, vitamin b6 deficiency anemia, malnutrition, malabsorption syndrome (small intestine), pregnancy, liver disease.

Vitamin A 

  • It is a Fat-soluble vitamin absorbed from the intestine in the presence of lipase and bile. Vitamin A moves to the liver and is then stored in the body as retinol.
  • Vitamin A is vital for normal vision, the immune system, reproduction, and growth and development.
  • Normal level: 30-65 µg/dL
  • Increased level: Hypervitaminosis, Chronic kidney disease
  • Decreased level: Night blindness, liver, intestinal, or pancreatic disease, chronic infections, cystic fibrosis, protein malnutrition, malabsorption, celiac disease

Vitamin B6

  • Vitamin B6, also known as pyridoxine, is a water-soluble vitamin your body needs for several functions. It’s significant to protein, fat, and carbohydrate metabolism and the creation of red blood cells and neurotransmitters.
  • Normal level: 5-30 ng/mL
  • Decreased level: Malnutrition, chronic alcoholism, gestational diabetes, pregnancy, lactation, small bowel inflammatory disease, renal failure.

Vitamin B12 

  • Vitamin B12 is a nutrient that helps keep the body’s nerve and blood cells healthy and helps make DNA, the genetic material in all cells. Vitamin B12 also helps prevent a type of anemia.
  • Normal level: 130-700 ng/L
  • Decreased level: Pernicious anemia, malabsorption syndrome, liver diseases, hypothyroidism (myxedema), pancreatic insufficiency, Crohn’s disease.
  • Increased level: Acute hepatitis, leukemia.

Vitamin C 

  • Ascorbic acid is a water-soluble vitamin important for forming collagen and certain amino acids for wound healing and withstanding stress, injury, and infection. 
  • Normal level: 0.4-1.5 mg/dL
  • Decreased levels: Scurvy, malabsorption, pregnancy, cancer, and severe burns. 

Vitamin D

  • Vitamin D is a fat-soluble vitamin occurring from exposure to the ultraviolet rays of sunlight and is absorbed in the presence of bile and stored in the liver. Vitamin D helps regulate the amount of calcium and phosphate in the body. These nutrients are needed to keep bones, teeth, and muscles healthy. 
  • Normal level:  5-75 ng/mL
  • Decreased level: Malabsorption, cirrhosis of the liver, rickets, osteomalacia, hypoparathyroidism, celiac disease, inflammatory bowel disease

Miscellaneous

Rheumatoid Factor

  • RF factor is a screening test used to detect antibodies (Igm, IgG, or Ig)
  • Normal level:  <25 IU/ml
  • Increased level: Rheumatoid arthritis, lupus, tuberculosis, leukemia

ESR 

  • An erythrocyte sedimentation rate (ESR) is a type of blood test that measures how quickly erythrocytes (red blood cells) settle in unclotted blood in millimeters per hour. 
  • It can show if you have inflammation in your body.
  • Normal level: >2 mm/h
  • Increased level: RA, rheumatic fever, AMI, Hodgkin’s disease, multiple myeloma, bacterial endocarditis, gout, hepatitis
  • Decreased level: Polycythemia vera, heart failure, sickle-cell anemias, factor V deficiency

ACE 

  • The ACE test measures the level of angiotensin-converting enzyme (ACE) in the blood.
  • Normal level: 20-50 µmol/L
  • Increased level: Sarcoidosis, Diabetes Mellitus, hypothyroidism, Respiratory distress syndrome
  • Decreased level: Therapy for sarcoidosis, diabetes mellitus, hypothyroidism

Lead

  • Found in lead-based paint, unglazed pottery, batteries, leaded gasoline
  • Normal level: < 25 IU/ml 
  • Higher levels can damage the kidneys and nervous system.

Refresh your memory and relearn the lab values by watching the full episode here 👇👇👇

TIMESTAMPS:

00:00 Introduction
01:21 About the episode
02:35 Electrolytes Potassium K+
Sodium Na+
Calcium Ca+
Chloride CI-
Magnesium Mg+
Phosphorus
Ammonia Uric acid
Creatinine
BUN
Specific Gravity
Lactic Dehydrogenase (LDH)
17:02 Hematology
RBC
WBC
Platelets (thrombocytes)
Hemoglobin (Hgb)
Hematocrit
Partial thromboplastin time (PTT)
Prothrombin Time (PT)
International Normalised Ratio (INR)
Reticulocytes
Neutrophils Bands
Lymphocytes
Monocytes
Eosinophils
HBA1C
Glucose
27:25 Gastrointestinal
Bilirubin
Albumin
ALT/AST
Amylase Lipase
30:40 Hormones
Hydroxyprogesterone
Adrenocorticotropic ACTH
Thyroid-Stimulating Hormone (TSH)
Thyroxine Follicle-Stimulating Hormone (FSH)
Human Growth Hormone (hGH)
Progesterone
Prolactin
Testosterone
36:57 Lipids Low-Density Lipoproteins (LDL)
High-Density Lipoproteins (HDL)
Triglycerides Total Cholesterol
39:11 Cardiac Markers
Creatine kinase
Troponin
C-Reactive Protein
D-Dimer
Brain Natriuretic Peptide (BNP)
41:56 Tumor Markers
Alpha-Fetoprotein (AFP)
CA 19-9 Carcinoembryonic Antigen (CEA)
Prostatic Acid Phosphatase (PAP)
Prostate-Specific Antigen (PSA)
44:15 Vitamins
Folate
Vitamin A
Vitamin B6
Vitamin B12
Vitamin C
Vitamin D
48:12 Miscellaneous
Rheumatoid Factor (RF)
Erythrocyte Sedimentation Rate (ESR)
Angiotensin-Converting Enzyme (ACE)
Lead

EP 199: The Renal System and RAAS

EP 199: The Renal System and RAAS

The Renal System

The renal system produces, stores, and eliminates urine. Kidneys make urine by filtering wastes and extra water from the blood. Urine travels from the kidneys through two thin tubes called ureters and fills the bladder.

When the bladder is full of urine, a person urinates through the urethra to eliminate the waste.

Functions of the Kidneys

The kidneys are located on either side of the spine at the lowest level of the rib cage, consisting of the functional unit called a nephron. 

There are about one million nephrons in each kidney; these nephrons consist of tiny blood vessels called glomerulus attached to a tubule. 

When blood enters the glomerulus, it is filtered, and the remaining fluid passes to the tubule. In the tubule, minerals, elements, chemicals, and water are absorbed or filtered according to the body’s needs to create the final product, urine.

Our kidneys maintain a delicate balance of water and electrolytes in the body and remove excessive waste:

  • Remove wastes, urea, and ammonia, from the blood.
  • Maintain fluid status balance in the body by holding or retaining water and releasing and removing water from the bloodstream
  • It maintains the electrolyte balance of the blood.
  • Maintain acid-base/pH balance of the blood
  • Assist with endocrine functions such as the production of erythropoietin and calcitriol.
    • It is needed to produce red blood cells and calcium reabsorption, respectively.
  • Produce the enzyme renin
    • Help regulate blood pressure.
  • Convert vitamin D into its active form

Fun Fact: 

  • Every 24 hours, your kidney filters 200 quarts of fluid. About two quarts are removed from the body, and 198 quarts are returned to the bloodstream. 
  • The right kidney sits lower than the left kidney. 
    • It helps accommodate the large size of the liver, right above the right kidney.
  • We call it REabsorption rather the just absorption because the substances filtered from the glomerulus were already absorbed through the GI tract and taken into the bloodstream.
  • Then the substances travel through the body via the heart and are sent to the kidneys through the renal artery to be filtered out. Therefore, our body reabsorbs these nutrients based on their needs, and the leftovers are excreted in the urine.

Anatomy of the Kidney

As a nurse and a nursing student, you’ll need to know these most critical parts of the kidney to understand how the renal system works.

Renal Capsule 

  • The outer layer of the kidney protects the kidney from outside organ infections. 

Renal cortex: 

  • A layer outside contains the renal corpuscles, which house the glomerulus and Bowman’s capsule, whose primary functions are to FILTER the urine and renal tubules. 

Renal medulla: 

  • The inside layer is located within the renal pyramids. It is hypertonic and very salty. Along with the nephron, these conditions help maintain water and salt balance in our body, specifically the Loop of Henle.

Renal artery:  

  • The renal artery takes oxygenated blood from the heart and moves it to the kidney to be filtered. It branches off around the renal columns into the renal cortex, into arterioles, and finally to the peritubular capillaries.

Renal vein:

  • The renal veins take filtered blood to heart for re-oxygenation and are pumped throughout the body. It comes from the efferent arterioles.

Renal pyramids: 

  • Lie Within the renal medulla contains the loop of Henle and parts of the collecting tubule.

Renal papilla, minor and significant calyx:

  • Pointed projections of the renal pyramid play a role in draining urine along with the renal pelvis, ureters, bladder, and urethra.

Nephrons: 

  • The functional part of the kidneys. 
  • Filters the blood via the renal corpuscle
  • Reabsorbs minerals/water and secretes waste via the renal tubule
  • Produces urine which drains down into the ureters, is stored in the bladder, and voided out via the urethra.
  • Each nephron is composed of 
    • Renal corpuscle (glomerulus within Bowman’s capsule)
    • Proximal tubule
    • An intermediate tubule (loop of Henle)
    • A distal convoluted tubule, a connecting tubule, and cortical, outer medullary, and inner medullary collecting ducts.

Glomerulus:

  • Lies within the nephron
  • Circular capillaries that have incredibly high pressure helps perform ULTRAFILTRATION.

Bowman’s capsule

  • Forms a cup-like sack around the glomerulus
  • It helps the glomerulus filter blood 

The Nephron and blood supply

Blood enters the afferent arteriole and sends blood to the first part of the nephron, called the glomerulus.

In the glomerulus, blood will be filtered, and filtrate will be created, a liquid consisting of the collection of fluid and particles from the blood.

The filtrate will “drip” down into a capsule surrounding the glomerulus called Bowman’s capsule.

  • Bowman’s capsule collects the filtrate.
    • Water, NA, CL, CA, K, Mg, Phos, Bicarb, amino acids, glucose, creatinine, and urea.

Then the filtered blood exits via the efferent arterioles to the peritubular capillaries surrounding the nephrons. 

Peritubular capillaries carry the reabsorbed nutrients from the filtrate back into the body’s system to the renal vein. They secrete urea, ions, and drugs in the blood into the tubules.

The created filtrate then flows through the proximal convoluted tubule (PCT); here, the tubule reabsorbs most of the parts of the filtrate that we need to function that just came from the Bowman’s capsule.

Then the filtrate enters the Loop of Henle; we are now in the renal medulla. The loop of Henle has a descending limb and ascending limb. Its goal is to concentrate the urine via the renal medulla.

The renal medulla’s interstitial fluid is hypertonic, helping reabsorb water from the filtrate to maintain the body’s water and salt balance.

  • Descending limb is only permeable to water.
  • Ascending limb is only permeable to ions.

The filtrate then enters the distal convoluted tubule, where more substances are reabsorbed and secreted. 

Then it travels to the collecting tubule, where parts of the filtrate are reabsorbed.

Finally, the filtrate leaves the collecting tubule as urine which flow through the renal papilla, minor/major calyx, renal pelvis, ureters, bladder, and urethra.

Kidney and Blood Pressure Management 

The renin-angiotensin-aldosterone system (RAAS) is the system of hormones, proteins, enzymes, and reactions that regulate your blood pressure and blood volume long-term.

It regulates your blood pressure by increasing sodium (salt) reabsorption, water reabsorption (retention), and vascular tone (the degree to which your blood vessels constrict or narrow). The RAAS consists of three major substances including:

  • Renin (an enzyme).
  • Angiotensin II (a hormone).
  • Aldosterone (a hormone).

RAAS System

  • Increases blood pressure when it drops too low by activating Angiotensin II
    • Angiotensin II increases vasoconstriction, causing an increase in blood pressure. Conserves sodium and water to increase volume. Aldosterone and ADH are released. 
  • RAAS steps
  1. Blood pressure drops too low. 
  2. The sympathetic nervous system sends nerve impulses to Juxtaglomerular Cells in the kidneys to release RENIN.
  3. RENIN present in the blood will activate ANGIOTENSINOGEN in the liver.
  4. ANGIOTENSINOGEN then turns into ANGIOTENSIN I causing a release of ACE
  5. ACE is Angiotensin-Converting Enzyme. ACE converts Angiotensin I into ANGIOTENSIN II
  6. ANGIOTENSIN II activation will cause
  7. Vasoconstriction
    • Increases systemic vascular resistance (SVR) and blood pressure.
  1. Increase Blood Volume
      • Kidneys will keep water and sodium.
      • The adrenal cortex gland will be triggered by angiotensin II to release aldosterone. Aldosterone will also cause the kidneys to keep sodium and water and excrete potassium.
    • Angiotensin II triggers the pituitary gland to release ADH. It causes the kidneys to keep water.

2. Increased blood pressure

To learn more about the renal system, click here for the full episode 👇👇👇

TIMESTAMPS:

00:00 Introduction
02:10 The functional parts of the kidney
03:18 What does a kidney do
04:40 Kidney fun facts
05:40 Anatomy of the kidney
10:00 The nephron and blood supply
15:48 Kidney and blood pressure management
17:39 How the Renin-Angiotensin-Aldosterone System (RAAS) works
21:50 Further views on the episode
24:02 Wrapping up the show